Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.
- Premarin 0.625 mg
- Active Ingredient: conjugated estrogens
- Premarin as known as: Cenestin, Climopax, Elredin, Enjuvia, Neradin, Premphase, Prempro, Presomen
It facilitates or eliminates the manifestations of a menopausal syndrome (feeling of heat, sweating, dizziness, irritability, depression), prevents the development of osteoporosis, normalizes the menstrual cycle in women of childbearing age, reduces the level of testosterone in men. The medicine regulates the development and preservation of the function of the female reproductive system, the formation of secondary sexual characteristics.It relieves or stops manifestations of irritability, anxiety, depression, and urogenital ( progressive diffuse atrophy of the external genitals) symptoms.
Getting into the blood system the remedy creates a complex with specific receptors, activates the synthesis of DNA and proteins. In this case, there is a proliferation of the upper layer of the skin. The cure increases the sensitivity of the uterine muscles and tubes to excite their motility.
It weakens bone resorption of Ca2+ during a midlife crisis, eliminates the involution of the genitals. It has a hypolipidemic effect, lowers the concentration of LDL in the blood, increases-HDL, susceptibility to insulin, improves glucose processing; activates the production of liver globulins binding sex hormones – renin and blood clotting factors; affects the metabolism of Ca2+ and phosphorus (helps to preserve the normal structure of bones, partly contributes to the growth of the skeleton and its final formation).
In large doses, the medicine inhibits water and Na+ in the body, delays erythropoiesis. Due to participation in the implementation of positive and negative reaction in the system, the substance causes restrained central effects. It eliminates expression of the climacteric syndrome: a feeling of heat, increased sweating, dizziness, irritability, depression; cancel the beginning of osteoporosis after a menopause. The remedy also supports the normalization of menstruation in women. As for men, it lowers testosterone levels.
Amenorrhea is a symptom in which girls or women do not menstruate. If a similar condition is observed in persons under 16 years of age, it is called primary amenorrhea. And if menstruation is not observed for three months or longer in women who have not previously had such problems, then we are talking about secondary amenorrhea.
What types of amenorrhea are there?
It is customary to distinguish the following types of amenorrhea:
- true (no characteristic changes occur in the endometrium and ovaries);
- false (the reproductive system works as it should, but for some reason menstrual blood does not come out of the vagina);
- physiological (pre-puberty, menopause, pregnancy, lactation);
- pathological (primary, secondary, etiotropic);
- iatrogenic (after surgery).
It is important to understand that amenorrhea is not an independent diagnosis, but only a symptom, therefore, if there are irregularities in the menstrual cycle, you should consult your doctor.
What causes amenorrhea?
Primary amenorrhea can develop due to the following reasons:
- anatomical features;
- genetic predisposition;
- psychological problems.
Secondary amenorrhea can develop due to factors such as:
- delayed puberty;
- pregnancy and lactation;
- endocrine disorders;
- taking hormonal medications, oral contraceptives and psychotropic drugs (including antidepressants);
- neoplasms in the pituitary gland that affect the production of prolactin;
- early menopause;
- surgical intervention;
- head injuries;
- Stein-Leventhal syndrome (polycystic ovary syndrome);
- prolonged stress;
- excessive physical activity;
- infectious diseases;
- radiation therapy.
How is amenorrhea diagnosed?
If you suspect amenorrhea, you need to contact a gynecologist who will conduct an examination, do an ultrasound and prescribe a blood test for hCG levels to rule out pregnancy.
If pregnancy is excluded, then check:
- level of sex hormones;
- concentration of thyroid hormones and their ratio;
- blood glucose level;
- the body’s reaction to taking and subsequent withdrawal of progesterone.
Sometimes, if the cause is not completely clear, additional research may be needed:
- consultation with a geneticist, endocrinologist, psychiatrist and neurologist;
- X-ray, CT and MRI of the head to detect tumors;
- endoscopic examination of the uterus and abdominal cavity;
Why is amenorrhea dangerous?
If you have amenorrhea, you cannot get pregnant; in addition, due to hormonal imbalances, a woman may be bothered by the following symptoms:
- disorders of the gastrointestinal tract;
- discharge from the mammary glands;
- depressed mood;
Lack of estrogen can lead to the development of diabetes, osteoporosis and cardiovascular diseases. The risk of developing malignant neoplasms also increases.
How to treat amenorrhea?
Depending on the type of amenorrhea, as well as the severity of this symptom, treatment can be either medicinal or surgical.
Surgical treatment is indicated in cases where women have congenital or acquired anatomical anomalies. But the most common drug therapy. One drug that has been successfully used to treat amenorrhea is Premarin.
What does Premarin do?
Premarin is a drug based on conjugated estrogens, which are highly soluble in water and are absorbed into the bloodstream from the gastrointestinal tract, from where they enter the tissues and bind to special receptors. Estrogens regulate the functions of the female reproductive system, thereby successfully eliminating the manifestations of both primary and secondary amenorrhea.
I have already finished taking Premarin and I can say that I am happy. Within six months of taking it, I entered menopause, and menopausal symptoms became less noticeable. The drug has been incredibly effective and I really appreciate it. I feel calmer and can even allow myself to be more energetic. I am very glad that I found Premarin and recommend it to all women suffering from menopausal and menopausal conditions.
I take Premarin to fight prostate cancer. This drug gives a high result: it quickly cures the disease and restores strength and health. It is important that Premarin is taken only on the recommendation of a doctor. For me, this drug is a real Friend, because it really helps in the fight against the disease. I can confidently recommend Premarin for the treatment of malignant neoplasms of the prostate gland.
How to take Premarin for amenorrhea?
Premarin is most often prescribed in intermittent courses of 2.5-7.5 mg daily for 20 days. On the 15th day, a gestagen is added and the appearance of menstrual bleeding is observed. If it appears at the end of treatment, the medications are stopped for five days and then continued again.
What side effects may occur while taking Premarin?
Premarin may cause the following side effects:
- swelling of the mammary glands and increased sensitivity;
- increased libido;
- vaginal discharge;
- disorders of the digestive system (loss of appetite, nausea, upset stomach, vomiting);
- headaches (including migraines)
Premarin is not recommended for bedridden patients or those planning surgery due to the risk of thrombosis and thromboembolism.
Can Premarin be taken with other medications?
Premarin may enhance the effect of lipid-lowering drugs and weaken the effect of antidepressants, diuretics, male sex hormones, indirect anticoagulants, drugs for hypertension and hypoglycemic drugs. In addition, the effectiveness of Premarin may be enhanced in combination with folic acid and thyroid medications, and may also be impaired by concomitant use of barbiturates, butadione, rifampicin, phenytoin and phenylbutazone.
What symptoms may occur with an overdose of Premarin?
An overdose of Premarin is accompanied by nausea, vomiting and bleeding, so if you suspect an overdose, you should urgently seek medical help.
Where can you buy Premarin?
How to Buy Premarin Over-the-Counter? Premarin can be bought at a pharmacy, or ordered online without a doctor’s prescription.
On this site you will find a link to a verified online pharmacy where you can buy the required drug. Delivery is carried out anonymously and to any place (by mail). You do not need a prescription to order; payment can be made in any convenient way.
Is it safe to buy generic Premarin?
A generic is a cheap analogue of the original drug, produced with a similar active ingredient in the same dosage (0.625 mg). Its cost is lower because its production does not require clinical trials, because the active substance (conjugated estrogens) already has proven effectiveness. Before buying the drug, you should consult your doctor.